EFFECTS OF FELBAMATE AND OTHER ANTICONVULSANT DRUGS IN 2 MODELS OF STATUS EPILEPTICUS IN THE RAT

被引：0
|
作者：
SOFIA, RD
GORDON, R
GELS, M
DIAMANTIS, W
机构：
来源：
RESEARCH COMMUNICATIONS IN CHEMICAL PATHOLOGY AND PHARMACOLOGY | 1993年 / 79卷 / 03期
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R36 [病理学];
学科分类号：
100104 ;
摘要：
Felbamate was compared with several antiepileptic drugs for protective effects in two rat models of status epilepticus. Felbamate was ten times more potent against pilocarpine-induced seizures in lithium-treated rats than in lithium-free animals. Diazepam, valproate and phenobarbital were effective in both the high dose pilocarpine and lithium-pilocarpine models. On the other hand, phanytoin was ineffective in both models, whereas carbamazepine displayed protective effects only in the lithium-pilocarpine model.
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页码：335 / 341
页数：7
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