INTERACTION WITH DNA OF THE NOVEL CATIONIC COMPLEX (2,2'-6',2''-TERPYRIDINE)METHYL PLATINUM(II)

被引：4
|
作者：
ROMEO, R
ARENA, G
SCOLARO, LM
PASTERNACK, RF
机构：
[1] CNR, ICTPN, SEZ MESSINA, MESSINA, ITALY
[2] SWARTHMORE COLL, DEPT CHEM, SWARTHMORE, PA 19081 USA
来源：
NUOVO CIMENTO DELLA SOCIETA ITALIANA DI FISICA D-CONDENSED MATTER ATOMIC MOLECULAR AND CHEMICAL PHYSICS FLUIDS PLASMAS BIOPHYSICS | 1994年 / 16卷 / 09期
关键词：
D O I：
10.1007/BF02462037
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
The planarity and electron delocalization of the 2,2':6',2 ''-terpyridine (terpy) moiety in salts of the type [Pt(terpy)Me]X leads to extensive stacking interactions in aqueous solution. IV/VIS, H-1 NMR and resonance light scattering spectra provide evidence for the tendency of the complex to form large aggregates even under low ionic strength conditions. The interaction of the cationic complex with calf thymus DNA was investigated by spectroscopic techniques and mobility assays. At high r(f) ratios the complex seems to form extended aggregates on the surface of the nucleic acid but at lower r(f) evidence was obtained for intercalation.
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页码：1523 / 1528
页数：6
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