IDENTIFICATION AND QUANTITATION OF NUCLEOSIDES, BASES AND OTHER UV-ABSORBING COMPOUNDS IN SERUM, USING REVERSED-PHASE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY .2. EVALUATION OF HUMAN-SERA

被引：134

作者：

HARTWICK, RA

KRSTULOVIC, AM

BROWN, PR

机构：

[1] Department of Chemistry, University of Rhode Island, Kingston

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 186卷 / DEC期

关键词：

D O I：

10.1016/S0021-9673(00)95286-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The reversed-phase mode of high-performance liquid chromatography was used to investigate the profiles of low-molecular-weight, UV-absorbing compounds in human serum. Identification techniques are described which allow for the identification of picomole amounts of the nucleosides, bases and other compounds in several microliters of serum ultrafiltrate. The sera from 31 normal subjects (17 males, 14 females) showed very consistent profiles. A total of 12 compounds were identified and quantified in normal serum. The analysis of sera from over 150 patients with various types of neoplasia and other diseases showed serum profiles significantly different from normal profile. © 1979.

引用

页码：659 / 676

页数：18

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[1] PURINE AND PYRIMIDINE EXCRETION IN NORMAL AND LEUKEMIC SUBJECTS [J].