STABILIZATION OF THYMOPENTIN AND PRESERVATION OF ITS PHARMACOLOGICAL PROPERTIES BY 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN

被引：6
|
作者：
BROWN, ND
BUTLER, DL
CHIANG, PK
机构：
[1] Department of Applied Biochemistry, Walter Reed Army Institute of Research, Washington, District of Columbia
来源：
JOURNAL OF PHARMACY AND PHARMACOLOGY | 1993年 / 45卷 / 07期
关键词：
D O I：
10.1111/j.2042-7158.1993.tb05675.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Thymopentin prepared in 5, 15, and 20% 2-hydroxypropyl-beta-cyclodextrin (HPCD) was able to inhibit guinea-pig ileum contraction stimulated by anatoxin-a (3 x 10(-6) M) after fourteen months of storage at room temperature. Thus, in contrast to the instability of thymopentin prepared without HPCD, the pharmacological activity was retained and could be stored in a ready-to-use solution for extended periods without refrigeration.
引用
收藏
页码：666 / 667
页数：2
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