Advances in the optimized synthesis of biotechnologically valuable products from bio-engineered microbial cell factories

被引:0
|
作者
Halevas, Eleftherios G. [1 ]
Pantazaki, Anastasia A. [1 ]
机构
[1] Aristotle Univ Thessaloniki, Dept Chem, Lab Biochem, Thessaloniki 54124, Greece
来源
BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY | 2018年 / 8卷 / 04期
关键词
Microbial cell factories; Biotechnological products; Metabolic bio-engineering; High added-value products; Synthetic biology;
D O I
暂无
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
The constantly arising solicitousness for the environmental impact and the potential limitation of petroleum and gas resources has focused the commercial interest on the development of industrially viable microbial strains with fine-tuned physiological capabilities. Synthetic biology, metabolic and protein engineering have become progressively important and valuable platforms in the development of microbial cellular networks for the generation of various pharmaceuticals, chemicals, food ingredients, and biofuels through the conversion of renewable resources. However, despite the comprehensive optimization of the biosynthetic pathways, the mass concentration and the low production rates represent the major obstacles in the exploration of new production hosts, the synthesis of novel enzymatic catalysts of natural and unnatural reactions, and the development of more effective tools for functional proteomics and genomics. Therefore, innovative synthetic biology research and diversified genome engineering approaches are anticipated to play the principal role in the achievement of engineered microbes with robust phenotypes, higher yields, and productivity. Herein, we thoroughly present the nascent technologies in the advancement of bio-engineered microbial cell factories for the optimized synthesis of biotechnologically valuable products.
引用
收藏
页码:3463 / 3482
页数:20
相关论文
共 15 条
  • [1] Biosynthesis of Fatty Alcohols in Engineered Microbial Cell Factories: Advances and Limitations
    Krishnan, Anagha
    McNeil, Bonnie A.
    Stuart, David T.
    FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 2020, 8
  • [2] Advances in the synthesis of menaquinone using microbial cell factories
    Sun, Panxing
    Li, Feng
    Zong, Yiwu
    Song, Hao
    CHINESE SCIENCE BULLETIN-CHINESE, 2022, 67 (34): : 4055 - 4067
  • [3] Industrial–scale production of various bio–commodities by engineered microbial cell factories: Strategies of engineering in microbial robustness
    Jung, Ju-Hyeong
    Ponnusamy, Vinoth Kumar
    Kumar, Gopalakrishnan
    Igliński, Bartlomiej
    Kumar, Vinod
    Piechota, Grzegorz
    Chemical Engineering Journal, 2024, 502
  • [4] Recent advances in itaconic acid production from microbial cell factories
    Gopaliya, Deeksha
    Kumar, Vinod
    Khare, Sunil Kumar
    BIOCATALYSIS AND AGRICULTURAL BIOTECHNOLOGY, 2021, 36
  • [5] Industrial-scale production of various bio-commodities by engineered microbial cell factories: Strategies of engineering in microbial robustness
    Jung, Ju-Hyeong
    Ponnusamy, Vinoth Kumar
    Kumar, Gopalakrishnan
    Iglinski, Bartlomiej
    Kumar, Vinod
    Piechota, Grzegorz
    CHEMICAL ENGINEERING JOURNAL, 2024, 502
  • [6] From pollutants to products: Microbial cell factories driving sustainable biomanufacturing and environmental conservation
    Gavrilescu, Maria
    CHEMICAL ENGINEERING JOURNAL, 2024, 500
  • [7] Microbial cell surface engineering for high-level synthesis of bio-products
    Wu, Xia
    Liu, Jingyi
    Liu, Zhiqiang
    Gong, Guoli
    Zha, Jian
    BIOTECHNOLOGY ADVANCES, 2022, 55
  • [8] Recent advances and prospects of Bacillus amyloliquefaciens as microbial cell factories: from rational design to industrial applications
    Luo, Zhengshan
    Yan, Yifan
    Du, Shanshan
    Zhu, Yifan
    Pan, Fei
    Wang, Rui
    Xu, Zheng
    Xu, Xiaoqi
    Li, Sha
    Xu, Hong
    CRITICAL REVIEWS IN BIOTECHNOLOGY, 2023, 43 (07) : 1073 - 1091
  • [9] Evolution of Vitamin E Production: From Chemical Synthesis and Plant Extraction to Microbial Cell Factories
    Yang, Jingyi
    Yu, Hongwei
    Ye, Lidan
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2024, : 27701 - 27714
  • [10] Engineering microbial cell factories for the production of plant natural products: from design principles to industrial-scale production
    Liu, Xiaonan
    Ding, Wentao
    Jiang, Huifeng
    MICROBIAL CELL FACTORIES, 2017, 16