PACKING OF ALPHA-HELICES IN GLOBULAR-PROTEINS - LAYER-STRUCTURE OF GLOBIN HYDROPHOBIC CORES

被引：68

作者：

EFIMOV, AV

机构：

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1979年 / 134卷 / 01期

关键词：

D O I：

10.1016/0022-2836(79)90412-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The packing of α-helices is considered in this paper. It is shown that close packing of hydrophobic side-chains on the surface of an individual α-helix or on the surface of the bihelical structure is obtained at a certain combination of rotational isomers. This allows the prediction of rotational isomers in α-helical regions of proteins. The theoretical analysis has been verified with cytochrome c and four globins. The results of theoretical prediction are in good agreement with experimental observation. © 1979.

引用

页码：23 / 40

页数：18

共 43 条

[1]

[Anonymous], 1968, ADV PHYS ORG CHEM

[2] STRUCTURAL INVARIANTS IN PROTEIN FOLDING [J].