SYNTHESIS OF 4 TRITIUM-LABELED AMINOWARFARIN METHYL KETAL REGIOISOMERS

被引：0

作者：

OBACH, RS ^{[1
]}

KAMINSKY, LS ^{[1
]}

机构：

[1] NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,POB 509,ALBANY,NY 12201

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 10期

关键词：

WARFARIN; CYCLOCOUMAROL; CATALYTIC TRITIATION;

D O I：

10.1002/jlcr.2580311005

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

6-Bromo-4'-nitro-, 4'-bromo-6-nitro-, 4'-bromo-7-nitro- and 4'-bromo-8-nitrowarfarin methyl ketals were prepared and together subjected to catalytic tritiation over palladium on charcoal to produce tritium-labelled aminowarfarin methyl ketals. The four regioisomers were separated by thin-layer chromatography to yield pure compounds of high (24.9-29.8 Ci/mmol) specific activity.

引用

页码：763 / 774

页数：12

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