Metanuclear Abnornmalities in Oral Premalignant and Malignant Lesions.

Cancer is a complex disease with altered expression, abnormal growth and disruption of normal function of cells caused by genotoxic effects of chemical carcinogens or environmental pollutants. The three most common fatal cancers were oral, stomach, lung in men. The aim of the study is to identify the occurrence of meta nuclear abnormalities KL, KR, BN) and to identify the occurrence of meta nuclear abnormalities in different stages of malignancy and to compare the incidence of metanuclear abnormalities in pre malignant and malignant conditions. A Total number of 25 pre malignant cases and 25 malignant cases and equal number of controls were included in our study. The material was collected and stained for Metanuclear abnormalities. Statistical analysis was done by standard t test. Metanuclear abnormalities in patients with oral carcinoma and pre malignant lesions in comparison with controls were found to be significant with the 'P' value of < 0.05 in our study.