Impedimetric Biosensors and Immunosensors

被引:0
|
作者
Prodromidis, Mamas I. [1 ]
机构
[1] Univ Ioannina, Dept Chem, Analyt Chem Lab, GR-45110 Ioannina, Greece
关键词
D O I
暂无
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
The development of methods targeting the direct monitoring of antibody-antigen interactions is particularly attractive. The design of label-free affinity-based probing concepts is the objective of much current research, at both academic and industrial levels, towards establishing alternative methods to the already existing ELISA-based immunoassays. Among these, Electrochemical Impedance Spectroscopy (EIS) represents one of the most powerful methods, due to the ability of EIS-based sensors to be more easily integrated into multi-array or microprocessor- controlled diagnostic tools. During the last decade, EIS and the concept of biochemical capacitors have been widely used for probing various types of biomolecular interactions (immunosensors, DNA hybridization, protein-protein interactions). So far, impedimetric or capacitive immunosensors have been successfully applied at the academic level. However, no prototypes have been released into the market, since major fundamental issues still exist. Even though this fact has brought the reliability of impedimetric immunosensors into question, features associated with electrochemical approaches, namely the ability to be miniaturized, remote control of implanted sensors, low cost of electrode mass production, and cost effective instrumentation (without need of high-energy sources) keep impedimetric sensors particularly attractive as compared to other approaches based on microbalances, surface plasmon resonance or ellipsometry. This lecture outlines the theoretical background of impedimetric immunosensors and presents different types of impedimetric biosensors as well as the instrumental approaches that have been so far proposed in the literature.
引用
收藏
页数:3
相关论文
共 50 条
  • [31] Nanomaterial-based biosensors and immunosensors for quantitative determination of cardiac troponins
    Nezami, Alireza
    Dehghani, Sadegh
    Nosrati, Rahim
    Eskandari, Negar
    Taghdisi, Seyed Mohammad
    Karimi, Gholamreza
    JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 159 : 425 - 436
  • [32] Development and study of anodic Ti/TiO2 electrodes and their potential use as impedimetric immunosensors
    Mantzila, AG
    Prodromidis, MI
    ELECTROCHIMICA ACTA, 2006, 51 (17) : 3537 - 3542
  • [33] Electropolymerized biotinylated poly (pyrrole-viologen) film as platform for the development of reagentless impedimetric immunosensors
    Gondran, Chantal
    Orio, Maylis
    Rigal, David
    Galland, Bruno
    Bouffier, Laurent
    Gulon, Tioga
    Cosnier, Serge
    ELECTROCHEMISTRY COMMUNICATIONS, 2010, 12 (02) : 311 - 314
  • [34] Stainless steel modified with an aminosilane layer and gold nanoparticles as a novel disposable substrate for impedimetric immunosensors
    Rezaei, Behzad
    Havakeshian, Elaheh
    Ensafi, Ali A.
    BIOSENSORS & BIOELECTRONICS, 2013, 48 : 61 - 66
  • [35] Comparison of Tetrapolar Injection-Measurement Techniques for Coplanar Affinity-Based Impedimetric Immunosensors
    Kassanos, Panagiotis
    Demosthenous, Andreas
    Bayford, Richard H.
    2008 IEEE BIOMEDICAL CIRCUITS AND SYSTEMS CONFERENCE - INTELLIGENT BIOMEDICAL SYSTEMS (BIOCAS), 2008, : 317 - +
  • [36] Impedimetric Biosensors for the Quantification of Serum Biomarkers for Early Detection of Lung Cancer
    Arabnejad, Mahdi
    Tothill, Ibtisam E.
    Chianella, Iva
    BIOSENSORS-BASEL, 2024, 14 (12):
  • [37] Label-free impedimetric biosensors for the control of food safety - a review
    Malvano, Francesca
    Pilloton, Roberto
    Albanese, Donatella
    INTERNATIONAL JOURNAL OF ENVIRONMENTAL ANALYTICAL CHEMISTRY, 2020, 100 (04) : 468 - 491
  • [38] Gold-coated carbon nanotube electrode arrays: Immunosensors for impedimetric detection of bone biomarkers
    Ramanathan, Madhumati
    Patil, Mitali
    Epur, Rigved
    Yun, Yeoheung
    Shanov, Vasselin
    Schulz, Mark
    Heineman, William R.
    Datta, Moni K.
    Kumta, Prashant N.
    BIOSENSORS & BIOELECTRONICS, 2016, 77 : 580 - 588
  • [39] Self-Enriching Electrospun Biosensors for Impedimetric Sensing of Zika Virus
    Frias, Isaac A. M.
    Gil, Laura Helena Vega Gonzales
    Cordeiro, Marli T.
    Oliveira, Maria D. L.
    Andrade, Cesar A. S.
    ACS APPLIED MATERIALS & INTERFACES, 2022, 14 (01) : 41 - 48
  • [40] Chemical sensors and biosensors based on impedimetric interdigitated electrode array transducers
    Chemical Transducers Group, Instituto de Microelectronica de Barcelona, Centro Nacional de Microelectrónica , Campus U.A.B, 08193 Bellaterra, Barcelona, Spain
    Chem. Sensors: Prop., Perform. and Appl., (91-116):