COMPARISON OF MIDAZOLAM PREMEDICATION WITH PLACEBO ON HEMODYNAMICS IN FEMALES UNDERGOING HYSTERECTOMY UNDER GENERAL ANESTHESIA

Background: Hysterectomy is the surgical removal of the uterus. Hysterectomy, in the literal sense of the word, means merely removal of the uterus. Midazolam, is a medication used in general anesthesia, procedural sedation, trouble sleeping, and severe agitation. The goal of pre-medication is to have the patient arrive in the operating room in a calm, relaxed frame of mind. But controversies in literature have been noticed. So we conducted this study. Objective: To compare the mean heart rate with midazolam premedication versus placebo in females undergoing hysterectomy under general anesthesia. Material & Methods:This randomized control study was conducted at department of anesthesiology, Sir Ganga Ram Hospital, Lahore for 6 months (Date: from-to-). The non-probability consecutive sampling technique was used. Informed consent was obtained and demographics of patients were noted. The participants were randomly divided in two groups by using lottery method. Baseline heart rate was measured by using ECG monitor. Group M was given midazolam 2 ml (i.e 2 mg) and group C was given 2 ml of physiological saline only, by a person not involved in taking observations. Then all patients followed-up till 15 minutes for assessment of heart rate. The data was entered and analyzed in SPSS version 20. Both groups were compared for mean heart rate by using t-test taking p-value <= 0.05 as significant. Results: In our study the mean age of the patients was 48.11 +/- 10.30 years and the mean HR value at baseline of the patients was 88.25 +/- 11.31 per minute. Statistically there is highly significant difference was found between the study groups and the HR value at baseline i.e. p-value=0.000. HR value after 15 minutes in midazolam group was 80.03 +/- 9.917 per minute and its mean value in placebo group was 81.03 +/- 10.052 per minute and insignificant difference was found between the study groups. i.e p-value=0.437. Conclusion: Our study results concluded that there is insignificant difference was found the mean heart rate after 15 minutes with midazolam premedication versus placebo in females undergoing hysterectomy under general anesthesia.