MAST-CELL DEGRANULATING PEPTIDE INDUCES THE EXPRESSION OF THE C-FOS PROTOONCOGENE IN HIPPOCAMPUS

被引：9
|
作者：
SEQUIER, JM [1 ]
LAZDUNSKI, M [1 ]
机构：
[1] CNRS,INST PHARMACOL MOLEC & CELLULAIRE,UPR 411,660 ROUTE LUCIOLES,F-06560 VALBONNE,FRANCE
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 180卷 / 01期
关键词：
Hippocampus; Hybridization (in situ); K[!sup]+[!/sup] channels; Plasticity;
D O I：
10.1016/0014-2999(90)90607-8
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The intrahippocampal injection of the mast cell degranulating (MCD) peptide, a bee venom component acting on the K+ channel, results in the appearance of the proto-oncogene c-fos mRNA in the ipsi- and contralateral hippocampus of the treated animals without generating convulsions. This MCD-induced transcriptional event is discussed in terms of cellular plasticity since MCD peptide is known to induce long-term potentiation. © 1990.
引用
收藏
页码：179 / 181
页数：3
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