GENOTOXICITY OF NATURALLY-OCCURRING HYDROXYANTHRAQUINONES

被引：178

作者：

WESTENDORF, J ^{[1
]}

MARQUARDT, H ^{[1
]}

POGINSKY, B ^{[1
]}

DOMINIAK, M ^{[1
]}

SCHMIDT, J ^{[1
]}

MARQUARDT, H ^{[1
]}

机构：

[1] FRAUNHOFER INST TOXICOL & AEROSOL RES,W-2000 HAMBURG 13,GERMANY

来源：

MUTATION RESEARCH | 1990年 / 240卷 / 01期

关键词：

Anthraquinones; Laxative drugs; Mutagenicity;

D O I：

10.1016/0165-1218(90)90002-J

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A variety of structurally related hydroxyanthraquinones (HA) were investigated in a test battery for the evaluation of mutagenicity and cell-transforming activity. The tests were: (1) the Salmonella typhimurium mutagenicity assay, (2) the V79-HGPRT mutagenicity assay, (3) the DNA-repair induction assay in primary rat hepatocytes and (4) the in vitro transformation of C3H/M2 mouse fibroblasts. In Salmonella, most of the tested compounds were mutagenic in strain TA1537, but only a few were active in other strains. Among these were HA with a hydroxymethyl group, such as lucidin and aloe-emodin. In V79 cells, only HA with 2 hydroxy groups in the 1,3 positions (1,3-DHA, purpurin, emodin) or with a hydroxymethyl sidechain (lucidin and aloe-emodin) were mutagenic. The compounds found to be active in V79 cells were also active in the DNA-repair assay and in the C3H/M2 transformation assay. Thus, it appears that the genotoxicity of HA is dependent on certain structural requirements. © 1990.

引用

页码：1 / 12

页数：12

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