REDISTRIBUTION OF SYNAPTIC VESICLES DURING LONG-TERM POTENTIATION IN THE HIPPOCAMPUS

被引：64

作者：

APPLEGATE, MD ^{[1
]}

KERR, DS ^{[1
]}

LANDFIELD, PW ^{[1
]}

机构：

[1] WAKE FOREST UNIV, BOWMAN GRAY SCH MED, DEPT PHYSIOL & PHARMACOL, 300 S HAWTHORNE RD, WINSTON SALEM, NC 27103 USA

来源：

BRAIN RESEARCH | 1987年 / 401卷 / 02期

关键词：

D O I：

10.1016/0006-8993(87)91429-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Synaptic vesicles were quantified 20 min after the induction of long-term potentiation (LTP) in the Schaffer-commissural system of the hippocampus. With LTP, significant increases were found in vesicles attached to the active zone membrane, and in the percentage of vesicles adjacent to the active zone. In addition, as others have reported, overall vesicle density was decreased and spine area was increased. These results suggest that an increased probability of vesicle release may contribute to brain LTP.

引用

页码：401 / 406

页数：6

共 31 条

[1]

ANDERSEN P, 1984, EXP BRAIN RES S, V9, P315

[2]

ANDERSEN P, 1975, HIPPOCAMPUS, V1, P155

[3]

APPLEGATE M D, 1986, Society for Neuroscience Abstracts, V12, P506

[4]

APPLEGATE M D, 1985, Society for Neuroscience Abstracts, V11, P895