Molecular and biological markers of the urinary bladder superficial and invasive cancer

The modern data on the molecular and genetic marker expression study in the urinary bladder tumors and their use in a differential diagnosis of the urinary bladder cancer is presented. It is demonstrated, that the morphological and molecular sign assessment of difference in a group of the urinary bladder noninvasive tumors is of greatest difficulty. The immunohistochemical and molecular absolute criteria of such difference are not yet described. Everything is solved in each certain case according to the aggregate of signs. It is possible to prognose a disease flow more precisely and timely correct a treatment only at a use of combination of several tissue markers with such well-known and widely used in practice prognostic factors, as a degree of tumoral invasion, multifocality of growth and a tumor anaplasia degree.