STRUCTURALLY SIMPLIFIED SQUALESTATINS - MONOCYCLIC 1,3-DIOXANE ANALOGS

被引：15
|
作者：
SHARRATT, PJ
HUTSON, JL
INGLIS, GGA
LESTER, MG
PROCOPIOU, PA
WATSON, NS
机构：
[1] Glaxo Group Research Ltd., Greenford
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 05期
关键词：
D O I：
10.1016/S0960-894X(01)80175-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Monocyclic analogues of squalestatin 1 based on a 1,3-dioxane ring were prepared and evaluated for their ability to inhibit squalene synthase in vitro. The compound 16a possessing a 4,6-dimethyloctenoyloxymethyl group at C4 and a carboxamide at C2 showed similar inhibitory activity to 1.
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页码：661 / 666
页数：6
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