K+ channel openers delay intestinal transit and have antidiarrheal activity

被引：28
|
作者：
Poggioli, R
Benelli, A
Arletti, R
Cavazzuti, E
Bertolini, A
机构：
[1] Department of Biomedical Sciences, Section of Pharmacology, University of Modena, 41100 Modena, MO
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1995年 / 287卷 / 02期
关键词：
K-ATP channel opener; pinacidil; cromakalim; morphine; intestinal transit; diarrhea;
D O I：
10.1016/0014-2999(95)00658-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The effect of pinacidil and cromakalim, two K-ATP channel openers, on intestinal transit and castor oil-induced diarrhea was studied in mice. Both drugs, administered orally, dose dependently inhibited the intestinal propulsion of charcoal, and castor oil-induced diarrhea, comparing favorably with morphine. These results may suggest a new approach for the symptomatic treatment of diarrhea.
引用
收藏
页码：207 / 209
页数：3
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