PRODUCTION OF MULTIPLE GROWTH-FACTORS BY A HUMAN NONSMALL CELL LUNG-CARCINOMA CELL-LINE

被引：7
|
作者：
OCCLESTON, NL [1 ]
WALKER, C [1 ]
机构：
[1] CLATTERBRIDGE HOSP,JK DOUGLAS CANC RES LABS,CLATTERBRIDGE CANC RES TRUST,BEBINGTON L63 4JY,ENGLAND
来源：
CANCER LETTERS | 1993年 / 71卷 / 1-3期
关键词：
GROWTH FACTORS; ENDOTHELIAL CELLS; NONSMALL CELL LUNG CANCER;
D O I：
10.1016/0304-3835(93)90117-R
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The IPT cell line, derived from an undifferentiated bronchial carcinoma, produced, in conditioned medium, immunoreactive basic fibroblast growth factor (bFGF), insulin-like growth factors I and II (IGF-I and IGF-II), epidermal growth factor (EGF), transforming growth factor alpha (TGFalpha), and transforming growth factor beta-2 (TGFbeta2) in its latent form, but not platelet-derived growth factor (PDGF), tumour necrosis factor alpha (TNFalpha), or transforming growth factor beta-1 (TGFbeta1). Comparative studies of growth stimulation of human umbilical vein (HUV) endothelial cells indicated that the growth factors detected in 1PT-conditioned medium do not solely account for its proliferative effects on these cells. These results support previous characterization studies [1,2] that suggest the production of a potentially novel tumour-derived endothelial cell growth factor by the 1PT cell line.
引用
收藏
页码：203 / 210
页数：8
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