IN-VITRO SENSITIVITY OF PLASMODIUM-FALCIPARUM TO DRUGS THAT BIND DNA OR INHIBIT ITS SYNTHESIS

被引：17
|
作者：
LEE, S
INSELBURG, J
机构：
[1] Department of Microbiology, Dartmouth Medical School, Hanover
来源：
JOURNAL OF PARASITOLOGY | 1993年 / 79卷 / 05期
关键词：
D O I：
10.2307/3283622
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
The in vitro sensitivity of Plasmodium falciparum to bleomycin, busulfan, camptothecin, CC-1065, cisplatin, duanomycin, distamycin, luzopeptin, mAMSA, mitomycin C, naladixic acid, U71184, VM 26, and VP16, or combinations of them was examined. The lethal dose concentration for 50% of parasites for 3 compounds, luzopeptin, CC1065, and U71184, that bind to adenine-thymidine-rich nucleotide sequences, were in the range of 10(-11) M. They were at least 2 orders of magnitude more effective than the other compounds.
引用
收藏
页码：780 / 782
页数：3
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