OPTIMIZATION OF FED-BATCH CULTURE OF HYBRIDOMA CELLS USING DYNAMIC-PROGRAMMING - SINGLE AND MULTI FEED CASES

被引：0
|
作者：
DETREMBLAY, M
PERRIER, M
CHAVARIE, C
ARCHAMBAULT, J
机构：
[1] ECOLE POLYTECH, MONTREAL H3C 3A7, QUEBEC, CANADA
[2] PULP & PAPER RES INST CANADA, MONTREAL H3A 2A7, QUEBEC, CANADA
[3] BIOTECHNOL RES INST, MONTREAL, QUEBEC, CANADA
来源：
BIOPROCESS ENGINEERING | 1992年 / 7卷 / 05期
关键词：
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The optimization of fed-batch culture of hybridoma cells is accomplished on a mathematical model using dynamic programming. Optimal feed trajectories are found using a seventh order model for a single feed stream containing both glucose and glutamine and for two separate feed streams of glucose and glutamine. Compared to a constant feed rate, optimal trajectories can improve the final MAb concentration by 11% for the single feed case and by 20% for the multifeed case. Higher MAb concentrations can be expected for fed-batch optimization with feed enriched in nutrients.
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页码：229 / 234
页数：6
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