The Structure and Activity of Double-Nitroimidazoles. A Mini-Review

被引：2
|
作者：
Zwawiak, Justyna [1 ]
Zaprutko, Lucjusz [1 ]
机构：
[1] Poznan Univ Med Sci, Dept Organ Chem, Pharmaceut Fac, Grunwaldzka 6, PL-60780 Poznan, Poland
来源：
SCIENTIA PHARMACEUTICA | 2018年 / 86卷 / 03期
关键词：
nitroimidazoles; double-nitroimidazoles; bis-nitroimidazoles; tumor hypoxia; radiosensitizers;
D O I：
10.3390/scipharm86030030
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Many interesting applications have been found for nitroimidazoles as therapeutic agents. Among others, some of these compounds can radiosensitize hypoxic tumor cells. The introduction of a second nitroimidazole ring to the molecule can improve the level of its pharmacological effect. The aim of this article is to overview the literature concerning active compounds that contain two nitroimidazole moieties in their structures.
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页数：10
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