A GENERAL-METHOD FOR CALCULATING THE MEAN TRANSIT TIMES AND DISTRIBUTION RATE PARAMETERS OF CATENARY METABOLITES

被引：1
|
作者：
CHENG, HY
机构：
[1] Department of Drug Metabolism, Merck Sharp and Dohme Research Laboratories, West Point, Pennsylvania
来源：
BIOPHARMACEUTICS & DRUG DISPOSITION | 1992年 / 13卷 / 03期
关键词：
MEAN TRANSIT TIME; RECYCLING NUMBER; METABOLITE; PRECURSOR; DISTRIBUTION RATE; PARAMETER;
D O I：
10.1002/bdd.2510130304
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A general method for calculating the mean transit times and distribution rate parameters is described. The calculations require the AUC, AUMC, and derivatives of the plasma concentration profiles of the metabolites and its precursor. The method is applicable to catenary metabolites with any precursor order and does not require separate administration of the metabolite. The approach is applied to published data for the primary and secondary metabolites of ketamine.
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页码：179 / 186
页数：8
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