EFFECT OF ANTACIDS ON THE DISSOLUTION BEHAVIOR OF TETRACYCLINE AND METHACYCLINE

The effect of antacids on the dissolution behavior of tetracycline hydrochloride and methacycline hydrochloride from commerical capsules was studied. The dissolution of the tetracyclines was retarded by antacids, i.e., aluminium silicate and magnesium trisilicate. An attempt was made to elucidate the mechanism of this effect. The effects of antacids on the dissolution may be due to the adsorption of the drugs on antacid particles and to the increased pH of the medium. The influence of stomachics using Cinnamomi Cortex as a test material was studied. In dissolution experiments on commercial capsules, a significant dissolution inhibition by the stomachic was found.