A CONVERGENT SYNTHESIS OF 2'-O-METHYL URIDINE

被引：20
|
作者：
PARMENTIER, G [1 ]
SCHMITT, G [1 ]
DOLLE, F [1 ]
LUU, B [1 ]
机构：
[1] UNIV STRASBOURG 1,CTR NEUROCHIM,CNRS,CHIM ORGAN SUBS NAT LAB,F-67084 STRASBOURG,FRANCE
来源：
TETRAHEDRON | 1994年 / 50卷 / 18期
关键词：
D O I：
10.1016/S0040-4020(01)80693-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convergent synthesis of 2'-O-methyl uridine (1) is described. The key steps in our synthesis are: (1) a facile obtention of the 2'-O-methyl sugar synthon using totally selective and efficient methylation conditions; (2) a stereoselective high-yield condensation with an uracil derivative, yielding the desired beta-form.
引用
收藏
页码：5361 / 5368
页数：8
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