Corneal neovascularization;
eye;
glaucoma;
microneedle;
ocular drug delivery;
D O I:
暂无
中图分类号:
R9 [药学];
学科分类号:
1007 ;
摘要:
Glaucoma and corneal neovascularization which is the world leading eye disease could be given new treatment options by use of tiny microneedles which are small enough to an unaided eye. Microneedles range in length from 400 to 700 mu m could provide a better medium of drug delivery into the eyes and thereby better disease management. The microneedle technology of drug delivery will be targeting specific to the eye and there by decrease the quantity of the drug and increase the effectiveness with minimal side effects. One of the leading causes of blindness is glaucoma, which happens when untreated and corneal neovascularization, causes an additional growth of blood vessels that damage the vision. Development of microneedle-based systems is being experimented with a way where the drug is precisely put into the part of the eye. Thus, coupling this delivery with a controlled release formulation may allow treating a condition for weeks or months. Thus, this review elucidates on the current research and the design which may act as a potential treatment for retinal disease.
机构:
Washington Univ, Sch Med, Dept Neurosurg, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Neurosurg, St Louis, MO 63110 USA
Zhu, Yanli
Zhang, Lihong
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Washington Univ, Sch Med, Dept Neurosurg, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Neurosurg, St Louis, MO 63110 USA
Zhang, Lihong
Gidday, Jeffrey M.
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机构:
Washington Univ, Sch Med, Dept Neurosurg, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Ophthalmol & Visual Sci, St Louis, MO 63110 USAWashington Univ, Sch Med, Dept Neurosurg, St Louis, MO 63110 USA
机构:
Malad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Hazam, Hadjer
Prades, Lucas
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机构:
Univ Paris Saclay, Inst Galien Paris Saclay, UMR CNRS 8612, Orsay, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Prades, Lucas
Cailleau, Catherine
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机构:
Univ Paris Saclay, Inst Galien Paris Saclay, UMR CNRS 8612, Orsay, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Cailleau, Catherine
Mougin, Julie
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机构:
Univ Paris Saclay, Inst Galien Paris Saclay, UMR CNRS 8612, Orsay, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Mougin, Julie
Feng, Jiao
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机构:
Univ Paris Saclay, Inst Galien Paris Saclay, UMR CNRS 8612, Orsay, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Feng, Jiao
Benhamou, Dan
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Malad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Benhamou, Dan
Gobeaux, Frederic
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机构:
Univ Paris Saclay, CEA Saclay, CNRS, NIMBE,UMR 3685,LIONS, Gif Sur Yvette, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Gobeaux, Frederic
Hamdi, Leila
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机构:
Malad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Hamdi, Leila
Couvreur, Patrick
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Univ Paris Saclay, Inst Galien Paris Saclay, UMR CNRS 8612, Orsay, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Couvreur, Patrick
Sitbon, Philippe
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机构:
Malad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Gustave Roussy, Dept Anesthesie Chirurg & Intervent, Serv Anesthesie, Villejuif, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France
Sitbon, Philippe
Lepetre-Mouelhi, Sinda
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机构:
Univ Paris Saclay, Inst Galien Paris Saclay, UMR CNRS 8612, Orsay, FranceMalad & Hormones Syst Nerveux, INSERM 1195, Le Kremlin Bicetre, France