INHIBITORY EFFECT OF AEROSOL WP871 ON SRS-A MEDIATED BRONCHOCONSTRICTION IN THE GUINEA-PIG INVIVO

被引：1
|
作者：
KURASHIMA, K
FUJIMURA, M
SAITO, M
SAKAMOTO, S
MIYAKE, Y
NISHI, K
MATSUDA, T
机构：
[1] The Third Department of Internal Medicine, Kanazawa University School of Medicine
来源：
ALLERGY | 1990年 / 45卷 / 04期
关键词：
allergic bronchoconstriction; anti‐allergic drug; WP871; guinea pig; LTC; SRS‐A;
D O I：
10.1111/j.1398-9995.1990.tb00492.x
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
Slow‐reacting substance of anaphylaxis (SRS‐A) is an important factor mediating bronchoconstriction in asthma. We developed a guinea pig model for SRS‐A mediated bronchoconstriction induced by antigen inhalation. Using this model, we investigated the effect of inhaled WP871, a new anti‐allergic drug, on bronchoconstriction. Aerosol WP871 (0.01 and 0.033%) to some extent inhibited the antigen‐induced bronchoconstriction in a dose‐dependent fashion, but high‐dose WP871 (0.1%) inhalation itself produced a non‐specific bronchoconstriction. However, aerosol WP871 (0.033%) showed no inhibitory effect on bronchoconstriction caused by direct inhalation of leukotriene C4, a component of SRS‐A. These findings indicate that aerosol WP871 does not antagonize SRS‐A, but inhibits synthesis and/or release of SRS‐A and has some non‐specific bronchoconstrictive effect in high concentration. Copyright © 1990, Wiley Blackwell. All rights reserved
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页码：249 / 253
页数：5
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