5-nitro isatin containing heterocyclics derivatives: synthesis, antioxidant activity, anticancer activity and molecular docking

被引：0

作者：

Rasheed, Hala Ayad Mohamed ^{[1
]}

Al-Majidi, Suaad M. H. ^{[1
]}

机构：

[1] Univ Baghdad, Coll Sci, Dept Chem, Baghdad, Iraq

来源：

NATURAL PRODUCT RESEARCH | 2023年

关键词：

5-nitro isatin; 1,2,4-triazine; diazino; pyridazine; anticancer;

D O I：

暂无

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The manuscript describes the synthesis of eight Novel 1,2,4-triazine and 1,2-diazino derivatives having the 5-nitro isatin moiety. Antiradical and anticancer activities were evaluated using the DPPH method and the MTT assay against breast cancer (MCF-7) cell lines. The compound with the strongest antioxidant and anticancer properties after 24 h was compound 9 (1,2,4-triazine-3-thione) but after 48 h, compound 7 (1,2,4- triazine-3-ol) with good anticancer activity while compound 11 (1,2-diazino) after 72 h.

引用

页数：10

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