SUPPRESSION OF CELLULAR NA+/H+ METABOLISM RESULTS IN INHIBITION OF INFLUENZA-VIRUS ACTIVITY

It was shown that amiloride, orthovanade and uabain induced almost a two-fold decrease in the rate of incubation medium oxidation by the chick embryo fibroblasts due to the Na+/H+ exchange and inhibited by more than 95 per cent the influenza virus activity. The following mechanism for inhibition of the influenza virus multiplication in the cells under the effect of the above mentioned substances was proposed: suppression of the cellular Na+/H+ exchange responsible for the decrease in pH value in the virus-carrying endosomes --> prevention of the decrease in the intraendosomal pH value to the critical level --> blocking of the acid dependent process of the virus uncoating --> inhibition of the influenza infection as a whole.