A MODIFIED MANNICH REACTION USING 1,3-DIOXOLANE

被引：0
|
作者：
SUMITA, K [1 ]
KOUMORI, M [1 ]
OHNO, S [1 ]
机构：
[1] MARUKO PHARMACEUT CO LTD, RES LABS, KASUGAI, AICHI 486, JAPAN
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 1994年 / 42卷 / 08期
关键词：
MANNICH REACTION; AMINOMETHYLATION; 1,3-DIOXOLANE; FORMALDEHYDE; PARAFORMALDEHYDE;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Mannich reaction of ketones using 1,3-dioxolane instead of formaldehyde, paraformaldehyde, or 1,3,5-trioxane afforded the corresponding Mannich bases in high yields. Under the same conditions the aminomethylation of aromatics did not proceed but the intramolecular aminomethylation, like a Pictet-Spengler type reaction, proceeded smoothly.
引用
收藏
页码：1676 / 1678
页数：3
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