1-ALPHA-HYDROXYVITAMIN D-3 INHIBITS TYPE-II COLLAGEN-INDUCED ARTHRITIS IN RATS

被引：40
|
作者：
TSUJI, M
FUJII, K
NAKANO, T
NISHII, Y
机构：
[1] JIKEI UNIV,SCH MED,DEPT ORTHOPAED SURG,MINATO KU,TOKYO,TOKYO 105,JAPAN
[2] CHUGAI PHARMACEUT CO LTD,RES LABS,TOSHIMA KU,TOKYO,TOKYO 171,JAPAN
来源：
FEBS LETTERS | 1994年 / 337卷 / 03期
关键词：
1-ALPHA-HYDROXYVITAMIN D-3; COLLAGEN-INDUCED ARTHRITIS; ANTI-TYPE II COLLAGEN ANTIBODY; RHEUMATOID ARTHRITIS;
D O I：
10.1016/0014-5793(94)80201-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The effects of 1 alpha-hydroxyvitamin D-3 and 24,25-dihydroxyvitamin D-3 on Type II collagen-induced arthritis in rats, an experimental model of rheumatoid arthritis, were examined. Oral administration of 1 alpha-hydroxyvitamin D-3 significantly suppressed the incidence of arthritis and inhibited hind paw swelling. The level of anti-Type II collagen antibodies was decreased in the 1 alpha-hydroxyvitamin D-3 treated-group. In contrast, 24,25-dihydroxyvitamin D-3, indomethacin, and gold had no effect on either the incidence of arthritis or the antibody levels. These findings demonstrate a beneficial effect of 1 alpha-hydroxyvitamin D-3 on Type II collagen-induced arthritis in rats and indicate that it has an antirheumatic effect.
引用
收藏
页码：248 / 250
页数：3
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