PREPARATION AND EVALUATION OF EUDRAGIT GELS .2. INVITRO RELEASE OF SALICYLIC-ACID, SODIUM-SALICYLATE, AND KETOPROFEN FROM EUDRAGIT-L AND EUDRAGIT-S ORGANOGELS

被引：17

作者：

KAWATA, M ^{[1
]}

SUZUKI, T ^{[1
]}

KIM, NS ^{[1
]}

ITO, T ^{[1
]}

KURITA, A ^{[1
]}

MIYAGOE, Y ^{[1
]}

GOTO, S ^{[1
]}

机构：

[1] KYUSHU UNIV,FAC PHARMACEUT SCI,3-1-1 MAIDASHI,HIGASHI KU,FUKUOKA 812,JAPAN

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1991年 / 80卷 / 11期

关键词：

D O I：

10.1002/jps.2600801115

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The in vitro dissolution characteristic of salicylic acid, sodium salicylate, and ketoprofen from Eudragit L and S organogels was investigated by the rotation disk method. The dissolution pattern of salicylic acid and erosion of Eudragit L polymer from the organogels followed apparent zero-order kinetics, providing strong evidence for a surface erosion mechanism and negligible diffusional release of salicylic acid. On the other hand, the dissolution of salicylic acid from Eudragit S organogels was a linear function of the square root of time. The apparent dissolution rate of salicylic acid from Eudragit S organogels increased with increasing temperature from 32 to 42-degrees-C and agitation rate from 50 to 200 rpm. A linear relationship was obtained between the logarithm of apparent dissolution rate constants and the reciprocal of absolute temperatures. The activation energy for release of salicylic acid from Eudragit S organogels was in the range of 2.99 to 5.57 kcal/mol. From various experimental results, it was concluded that the release process of salicylic acid from Eudragit S organogels was diffusion controlled through the organogels matrix.

引用

页码：1072 / 1074

页数：3