The article discusses about research of the outcomes assessment using sclerotherapy of thyroid nodules by percutaneous ethanol injection in adult patients with benign nodular thyroid neoplasms. Based on the obtained data during the literature search for the primary analysis were separated works meet the criteria of the clinical trial, used the data of the meta-analysis, as well as highlighted publication from not peerreviewed sources. In the studied literature we found, the conflicting views about the frequency, the amount and the concentration of injected ethanol, indications to the percutaneous ethanol injection, as well as the maximum size of the node, which can be subjected to sclerotherapy. Future research should be aimed at assessing the quality of life after the procedure, the registration of mortality, malignancy, comparing the advantages of minimally invasive procedures with surgery. The main development of the method should be use of the procedure at the level of primary health care organizations.