THE SYNTHESIS AND EVALUATION OF TRANS-6-(SUBSTITUTED-1-NAPHTHYL)ETHYL(OR ETHENYL)-3,4,5,6-TETRAHYDRO-4-HYDROXY-2H-PYRAN-2-ONES AS INHIBITORS OF HMG-COA REDUCTASE

被引：0
|
作者：
PRUGH, JD
ALBERTS, AW
DEANA, AA
GILFILLAN, JL
HUFF, JW
WIGGINS, JM
机构：
[1] MERCK SHARP & DOHME RES LABS,RAHWAY,NJ 07065
[2] MERCK SHARP & DOHME RES LABS,W POINT,PA 19486
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1987年 / 193卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：21 / MEDI
相关论文
共 50 条
  • [1] 3-HYDROXY-3-METHYLGLUTARYL-COENZYME-A REDUCTASE INHIBITORS .6. TRANS-6-[2-(SUBSTITUTED-1-NAPHTHYL)ETHYL(OR -ETHENYL)]-3,4,5,6-TETRAHYDRO-4-HYDROXY-2H-PYRAN-2-ONES
    PRUGH, JD
    ALBERTS, AW
    DEANA, AA
    GILFILLIAN, JL
    HUFF, JW
    SMITH, RL
    WIGGINS, JM
    JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (02) : 758 - 765
  • [2] TRANS-6-[2-(SUBSTITUTED-QUINOLINYL)ETHENYL]TETRAHYDRO-4-HYDROXY-2H-PYRAN-2-ONES, A NEW CLASS OF HMG-COA REDUCTASE INHIBITORS
    PICARD, JA
    SLISKOVIC, DR
    ROTH, BD
    NEWTON, RS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 198 : 73 - MEDI
  • [3] INHIBITORS OF CHOLESTEROL-BIOSYNTHESIS .4. TRANS-6-[2-(SUBSTITUTED-QUINOLINYL)ETHENYL/ETHYL]TETRAHYDRO-4-HYDROXY-2H-PYRAN-2-ONES, A NOVEL SERIES OF HMG-COA REDUCTASE INHIBITORS
    SLISKOVIC, DR
    PICARD, JA
    ROARK, WH
    ROTH, BD
    FERGUSON, E
    KRAUSE, BR
    NEWTON, RS
    SEKERKE, C
    SHAW, MK
    JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) : 367 - 373
  • [4] TRANS-6-[2-(SUBSTITUTED-PYRROL-1-YL)ETHYL]-4-HYDROXY-PYRAN-2-ONES, A NEW CLASS OF HMG-COA REDUCTASE INHIBITORS
    ROTH, BD
    HOEFLE, ML
    SLISKOVIC, DR
    STRATTON, CD
    WILSON, MW
    NEWTON, RS
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1987, 194 : 81 - MEDI
  • [5] INHIBITORS OF HMG-COA REDUCTASE - BIOLOGICAL EFFECTS OF A 6-[2-[2-(4-FLUORO-3-METHYLPHENYL)-4-SUBSTITUTED CYCLOHEX-1-EN-1-YL]ETHENYL]-4-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONE
    REGAN, JR
    BRUNO, JG
    GUSTAFSON, K
    AMIN, D
    NEUENSCHWANDER, K
    PERRONE, M
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1992, 27 (07) : 735 - 742
  • [6] INHIBITORS OF CHOLESTEROL-BIOSYNTHESIS .6. TRANS-6-[2-(2-N-HETEROARYL-3,5-DISUBSTITUTED-PYRAZOL-4-YL)ETHYL/ETHENYL]TETRAHYDRO-4-HYDROXY-2H-PYRAN-2-ONES
    SLISKOVIC, DR
    BLANKLEY, CJ
    KRAUSE, BR
    NEWTON, RS
    PICARD, JA
    ROARK, WH
    ROTH, BD
    SEKERKE, C
    SHAW, MK
    STANFIELD, RL
    JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (11) : 2095 - 2103
  • [7] INHIBITORS OF CHOLESTEROL-BIOSYNTHESIS .3. TETRAHYDRO-4-HYDROXY-6-[2-(1H-PYRROL-1-YL)ETHYL]-2H-PYRAN-2-ONE INHIBITORS OF HMG-COA REDUCTASE .2. EFFECTS OF INTRODUCING SUBSTITUENTS AT POSITIONS 3 AND 4 OF THE PYRROLE NUCLEUS
    ROTH, BD
    BLANKLEY, CJ
    CHUCHOLOWSKI, AW
    FERGUSON, E
    HOEFLE, ML
    ORTWINE, DF
    NEWTON, RS
    SEKERKE, CS
    SLISKOVIC, DR
    STRATTON, CD
    WILSON, MW
    JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) : 357 - 366
  • [8] Enantioselective synthesis of the lactone moiety of HMG-CoA reductase inhibitor: Stereoselective synthesis of (+)-(4R,6R)-4-hydroxy-6-(2-phenylethyl)-tetrahydro-2H-pyran-2-one
    Honda, T
    Ono, S
    Mizutani, H
    Hallinan, KO
    TETRAHEDRON-ASYMMETRY, 1997, 8 (02) : 181 - 184
  • [9] A CONVENIENT SYNTHESIS OF 5-SUBSTITUTED-4-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONES VIA A CHEMOSELECTIVE DIFFERENTIATION OF THE 2 ESTER FUNCTIONS OF DIMETHYL ACETONEDICARBOXYLATE
    PRUGH, JD
    DEANA, AA
    TETRAHEDRON LETTERS, 1988, 29 (01) : 37 - 40
  • [10] SYNTHESIS OF (+/-)-TRANS-6-[4,4-BIS(4-FLUOROPHENYL)-3-(1-METHYL-1H-TETRAZOL-5-YL)-1(E),3-[2-C-14]BUTADIENYL]-4-HYDROXY-3,4,5,6-TETRAHYDRO-2H-PYRAN-2-ONE
    LUKE, GM
    SWIGOR, JE
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1991, 29 (02): : 193 - 199
12345