Large Cell Neuroendocrine Carcinoma of the Uterine Cervix: A Rare Case Report

Large cell neuroendocrine carcinoma of the uterine cervix is a rare and aggressive malignancy with poor prognosis even in its early stage, despite multimodality treatment strategy. We describe a 37-year-old woman with a large cell neuroendocrine carcinoma admixed with adenocarcinoma of the uterine cervix. These highly aggressive tumors have a prognosis that is much worse than that for stage comparable poorly differentiated squamous cell carcinoma of the cervix. Aggressive initial multimodality treatment with radical hysterectomy, bilateral pelvic lymph node dissection and adjuvant chemotherapy is recommended.