TREATMENT OF ILOPERIDONE INDUCED EJACULATORY DYSFUNCTION WITH IMIPRAMINE

Prevalence of sexual and reproductive function side effects of atypical antipsychotics is 18 to 96% contributingto non-compliance in 50% of treated patients. 1 The abnormal ejaculation of semen is a typical and infrequent side effect of some alpha 1-adrenoceptor antagonists. Iloperidone, a new dopamine type 2/serotonin type 2A antagonist provides better efficacy with less extra-pyramidal symptoms than D2 receptor antagonist antipsychotics. Iloperidone additionally has high affinity for alpha1 receptors and moderate affinity for alpha-2C receptors.(2,3) Despite this knowledge, there is limited data regarding retrograde ejaculation caused due to use of Iloperidone. This article features three clinical cases of schizophrenia experiencing retrograde ejaculation after therapy with Iloperidone, treated successfully with Imipramine.