INVIVO EFFECTS OF CANDIDA-ALBICANS PRODUCTS ON RAT ORAL EPITHELIUM

被引：17
|
作者：
REED, MF [1 ]
SCRAGG, MA [1 ]
WILLIAMS, DM [1 ]
SOAMES, JV [1 ]
机构：
[1] UNIV LONDON LONDON HOSP,COLL MED,DEPT ORAL PATHOL,LONDON E1 2AD,ENGLAND
来源：
JOURNAL OF ORAL PATHOLOGY & MEDICINE | 1990年 / 19卷 / 07期
关键词：
Candida; cell kinetics; epithelium; oral; rat;
D O I：
10.1111/j.1600-0714.1990.tb00854.x
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
Candida albicans has been associated with epithelial hyperplasia in some diseases of oral mucosa and skin but its etiologic role in these lesions is poorly understood. To test its ability to induce epithelial proliferation, the invasive hyphal form was cultured for 5 h and 23 h in chemically defined medium and yeast‐free culture supernatants were injected below the buccal epithelium of young adult Sprague Dawley rats. The mitotic activity was assessed using the metaphase arrest technique 11 h and 31 h after supernatant injection. There was a significant increase in epithelial mitotic activity 31 h after injection with 5 h culture supernatants compared to control media indicating that the supernatants have an effect on epithelial cells, possibly by direct action on them. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码：326 / 329
页数：4
相关论文
共 50 条
12345