RELEASE OF MIGRATION INHIBITORY FACTORS FROM IMMUNE RAT LYMPHOCYTES CONFRONTED WITH HISTOCOMPATIBILITY ANTIGENS

被引：23

作者：

FALK, RE

COLLSTE, L

MOLLER, G

机构：

[1] Laboratory of Transplantation Immunology, Department of Bacteriology, Karolinska Institutet

来源：

NATURE | 1969年 / 224卷 / 5225期

关键词：

D O I：

10.1038/2241206a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

RODENT spleen cells migrate from capillary tubes in vitro and this migration of cells from animals sensitized to transplantation antigens is inhibited when the specific antigen is present1. Non-sensitized cells were not inhibited or exhibited a slight inhibition in similar conditions. This observation, comparable with results described by Al-Askari2,3, led to a study of the mechanism of the inhibition. In delayed hypersensitivity the release of a soluble protein substance from immune lymphocytes after stimulation with antigen has been demonstrated. This substance, termed migration inhibiting factor, has been shown to inhibit the migration of non-immune cells1,4-6,8,9. © 1969 Nature Publishing Group.

引用

页码：1206 / &

共 11 条

[1] IN VITRO STUDIES ON HOMOGRAFT SENSITIVITY [J].