MER-[RU(TERPY)CL-3] (TERPY=2,2'/6',2''-TERPYRIDINE) SHOWS BIOLOGICAL-ACTIVITY, FORMS INTERSTRAND CROSS-LINKS IN DNA AND BINDS 2 GUANINE DERIVATIVES IN A TRANS CONFIGURATION

被引：58

作者：

VANVLIET, PM

TOEKIMIN, SMS

HAASNOOT, JG

REEDIJK, J

NOVAKOVA, O

VRANA, O

BRABEC, V

机构：

[1] LEIDEN UNIV,LEIDEN INST CHEM,GORLAEUS LABS,2300 RA LEIDEN,NETHERLANDS

[2] ACAD SCI CZECH REPUBL,INST BIOPHYS,CR-61265 BRNO,CZECH REPUBLIC

来源：

INORGANICA CHIMICA ACTA | 1995年 / 231卷 / 1-2期

关键词：

ANTITUMOR ACTIVITY; RUTHENIUM COMPLEXES; TERPYRIDINE COMPLEXES; DNA COMPLEXES;

D O I：

10.1016/0020-1693(94)04320-U

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The compound mer-[Ru(terpy)Cl-3] was found to be active as a cytostatic in L1210 leukemia cells, with an activity in between cisplatin and carboplatin. It was shown that the Ru complex covalently binds to DNA and this binding results in the formation of similar to 2% interstrand cross-links. In addition, no Ru-promoted nicks are formed. The parent compound has also been reacted with the DNA model bases 9-methylhypoxanthine (9mhyp) and 9-ethylguanine (9egua). The solid complexes trans-[Ru(terpy)(B- kN(7))(2)(H2O)](PF6)(2), where B = 9mhyp or 9egua, were isolated and characterized in acetone solution by proton NMR. The bases are symmetrically arranged around the metal center, and involved in hydrogen bonding with the water ligand, most likely via their O6 atoms. The water ligand has been substituted by acetonitrile. The complexes trans-[Ru(terpy)(B-kN(7))(2)(CH3CN)](PF6)(2), where B = 9mhyp or 9egua, have been prepared in situ. Compared to the aqua complexes, the hydrogen bond donor molecule is lost and a rearrangement of the guanine bases is observed.

引用

页码：57 / 64

页数：8

共 5 条

[1] SYNTHESIS AND CHARACTERIZATION OF PHENYLIMIDORHEMIUM(V) COMPOUNDS CONTAINING POLYPYRIDYL LIGANDS - CRYSTAL-STRUCTURES OF MER-[RE(NPH)CL-3(BIPY)], TRANS-[RE(NPH)-(OET)(BIPY)(2)][PF6](2) AND TRANS-[RE(NPH)CL-2(TERPY)]PF6 (BIPY=2,2'-BIPYRIDINE, TERPY=2,2'/6',2''-TERPYRIDINE)
BAKIR, M
SULLIVAN, BP
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1995, (10): : 1733 - 1738
[2] REDOX PROPERTIES AND ELECTROCATALYTIC ACTIVITY OF THE OXO AQUA SYSTEM [RU(TERPY)(BPZ)(O)](2+)/[RU(TERPY)(BPZ)(H2O)](2+) - X-RAY CRYSTAL-STRUCTURE OF [RU(TERPY)(BPZ)CL]PF6-CENTER-DOT-MECN (TERPY=2,2',2''-TERPYRIDINE BPZ=2,2'-BIPYRAZINE)
GERLI, A
REEDIJK, J
LAKIN, MT
SPEK, AL
INORGANIC CHEMISTRY, 1995, 34 (07) : 1836 - 1843
[3] 2,2'/6',2''-TERPYRIDINE (TERPY) ACTING AS A FLUXIONAL BIDENTATE LIGAND .3. RUTHENIUM CARBONYL HALIDE-COMPLEXES, [RUX(2)(CO)(2)(TERPY)] (X=CL, BR OR I) AND METAL TETRACARBONYL COMPLEXES [M(CO)(4)(TERPY)] (M=CR, MO OR W) - NUCLEAR-MAGNETIC-RESONANCE STUDIES OF THEIR SOLUTION DYNAMICS AND SYNTHESIS OF TRANS-[RUX(2)(CO)(TERPY)] (X=CL, BR OR L)
ABEL, EW
ORRELL, KG
OSBORNE, AG
PAIN, HM
SIK, V
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS, 1994, (02): : 111 - 116
[4] SYNTHESIS AND CHARACTERIZATION OF MIXED-LIGAND TECHNETIUM(II) COMPLEXES CONTAINING HALIDES, PHOSPHINES, AND EITHER 2,2'-BIPYRIDINE, 1,10-PHENANTHROLINE, OR 2,2'-6',2''-TERPYRIDINE - X-RAY CRYSTAL-STRUCTURES OF CIS(CL),TRANS(P)-[TCCL2(P(CH3)2C6H5)2(PHEN)] AND TRANS(P)-[TCBR(P(CH3)2C6H5)2(TERPY)]SO3CF31
WILCOX, BE
HO, DM
DEUTSCH, E
INORGANIC CHEMISTRY, 1989, 28 (20) : 3917 - 3923
[5] New arylruthenium(II) complexes of the P,C,P'-coordinating terdentate monoanionic aryl ligands [C6H2(CH(2)PPh(2))(2)-2,6-R-4](-) (PCP-R-4; R=Ph,H). Synthesis of 16-electron species [Ru(II)X(PCP-R-4)(PPh(3))] (X=Cl,I,OTf) and their reactivity toward the neutral terdentate N-donor ligand 2,2':6',2''-terpyridine (terpy)
Karlen, T
Dani, P
Grove, DM
Steenwinkel, P
vanKoten, G
ORGANOMETALLICS, 1996, 15 (26) : 5687 - 5694

← 1 →