Genetic and epigenetic alterations of colorectal cancer

被引：94
|
作者：
Hong, Sung Noh [1 ]
机构：
[1] Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, 81 Irwon Ro, Seoul 06351, South Korea
来源：
INTESTINAL RESEARCH | 2018年 / 16卷 / 03期
关键词：
Colorectal neoplasms; Mutation; Epigenesis; genetic;
D O I：
10.5217/ir.2018.16.3.327
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Colorectal cancer (CRC) arise from multi-step carcinogenesis due to genetic mutations and epigenetic modifications of human genome. Genetic mutations and epigenetic modifications were originally established as 2 independent mechanisms contributing to colorectal carcinogenesis. However, recent evidences demonstrate that there are interactions between these 2 mechanisms. Genetic mutations enable disruption of epigenetic controls while epigenetic modifications can initiate genomic instability and carcinogenesis. This review summarized genetic mutations and epigenetic modifications in colorectal carcinogenesis and molecular classification of CRC subtype based on genetic or epigenetic biomarkers for treatment response and prognosis. Molecular subtypes of CRC will permit the implementation of precision medicine with better outcome of management for CRC.
引用
收藏
页码：327 / 337
页数：11
相关论文
共 50 条
  • [1] Integrated analysis of genetic and epigenetic alterations in colorectal cancerIntegrated analysis of genetic and epigenetic alterations in colorectal cancer
    Karpinski, Pawel
    Kozlowska, Joanna
    Bebenek, Marek
    Grzebieniak, Zygmunt
    Blin, Nikolaus
    Sasiadek, Maria Malgorzata
    CHROMOSOME RESEARCH, 2013, 21 : S82 - S82
  • [2] DNA fingerprinting techniques for the analysis of genetic and epigenetic alterations in colorectal cancer
    Samuelsson, Johanna K.
    Alonso, Sergio
    Yamamoto, Fumiichiro
    Perucho, Manuel
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2010, 693 (1-2) : 61 - 76
  • [3] Genetic and epigenetic alterations in young, non-familial colorectal cancer patients
    Jung, Woon-Tae
    Nagasaka, Takeshi
    Goel, Ajay
    Boland, C. R.
    GASTROENTEROLOGY, 2008, 134 (04) : A615 - A615
  • [4] Genetic and epigenetic alterations in colon cancer
    Grady, WM
    Markowitz, SD
    ANNUAL REVIEW OF GENOMICS AND HUMAN GENETICS, 2002, 3 : 101 - 128
  • [5] Genetic and Epigenetic Alterations in Bladder Cancer
    Li, Hong-Tao
    Duymich, Christopher E.
    Weisenberger, Daniel J.
    Liang, Gangning
    INTERNATIONAL NEUROUROLOGY JOURNAL, 2016, 20 : 84 - 94
  • [6] Epigenetic Alterations in Colorectal Cancer: Emerging Biomarkers
    Okugawa, Yoshinaga
    Grady, William M.
    Goel, Ajay
    GASTROENTEROLOGY, 2015, 149 (05) : 1204 - +
  • [7] Epigenetic Alterations by MicroRNAs in Carcinogenesis of Colorectal Cancer
    Hata, T.
    Yamamoto, H.
    Okuzaki, D.
    Ogawa, H.
    Konno, M.
    Takahashi, H.
    Haraguchi, N.
    Nishimura, J.
    Hata, T.
    Takemasa, I.
    Sato, T.
    Mizushima, T.
    Ishii, H.
    Doki, Y.
    Mori, M.
    ANNALS OF SURGICAL ONCOLOGY, 2016, 23 : S79 - S79
  • [8] Colorectal cancer: epigenetic alterations and their clinical implications
    Puccini, Alberto
    Berger, Martin D.
    Naseem, Madiha
    Tokunaga, Ryuma
    Battaglin, Francesca
    Cao, Shu
    Hanna, Diana L.
    McSkane, Michelle
    Soni, Shivani
    Zhang, Wu
    Lenz, Heinz-Josef
    BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER, 2017, 1868 (02): : 439 - 448
  • [9] PIK3CA mutation in colorectal cancer:: Relationship with genetic and epigenetic alterations
    Nosho, Katsuhiko
    Kawasaki, Takako
    Ohnishi, Mutsuko
    Suemoto, Yuko
    Kirkner, Gregory J.
    Zepf, Dimity
    Yan, Liying
    Longtine, Janina A.
    Fuchs, Charles S.
    Ogino, Shuji
    NEOPLASIA, 2008, 10 (06): : 534 - 541
  • [10] Detection of colorectal cancer-associated genetic and epigenetic alterations in urine of patients with CRC
    Clemens, Adam Winfield
    Lin, Selena
    Jain, Surbhi
    Su, Ying-Hsiu
    Song, Wei
    CANCER RESEARCH, 2015, 75
12345