BREAST-CANCER CYTOGENETICS AND BEYOND

被引：12
|
作者：
HAINSWORTH, PJ
GARSON, OM
机构：
[1] University of Melbourne, Departments of Surgery, Fitzroy, Victoria
[2] Medicine. St Vincent's Hospital, Fitzroy, Victoria
来源：
AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY | 1990年 / 60卷 / 05期
关键词：
breast neoplasms; chromosome abnormalities; cytogenetics; fragile sites; gene deletion; genetics; oncogences; prognosis;
D O I：
10.1111/j.1445-2197.1990.tb07379.x
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
It is hypothesized that cancers arise as a result of genetic or chromosomal alteration. Evidence for this provided by the leukaemias and lymphomas in which cytogenetic studies are of established value in diagnosis, classification and follow‐up. In contrast, the cytogenetic study of all solid turnours, including breast carcinoma, is in its infancy. However, cytogenetic studies indicate that clonal structural alterations do occur, affecting several loci on a number of chromosomes. Molecular studies provide further evidence of recurring chromosomal breakpoints breast cancer. This paper reviews the chromosomal rearrangements observed to date and discusses their relevance to the biology of breast cancer. Copyright © 1990, Wiley Blackwell. All rights reserved
引用
收藏
页码：327 / 336
页数：10
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