OBLIQUE ALIGNMENT OF HEMOGLOBIN-S FIBERS IN SICKLED CELLS

被引：24
作者：
EDELSTEIN, SJ
CREPEAU, RH
机构：
[1] Section of Biochemistry, Molecular and Cell Biology Cornell University Ithaca
来源：
JOURNAL OF MOLECULAR BIOLOGY | 1979年 / 134卷 / 04期
基金：
美国国家卫生研究院; 美国国家科学基金会;
关键词：
D O I：
10.1016/0022-2836(79)90491-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Thin sections of embedded, sickled erythrocytes reveal oblique alignment of parallel sheets of single fibers of hemoglobin S, with adjacent layers rotated by about 26 °. The oblique alignment pattern is consistent with the interlocking of helical grooves present in the 14-filament structure determined for individual fibers and could be related to the curvature in cell shape characteristic of the sickling process. © 1979.
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收藏
页码：851 / 855
页数：5
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