THE EMERGENCE OF THE CHAPERONE MACHINES

被引：232
作者：
GEORGOPOULOS, C
机构：
[1] Département de Biochimie Médicale, Centre Médical Universitaire, CH-1211 Geneve 4
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1992年 / 17卷 / 08期
关键词：
D O I：
10.1016/0968-0004(92)90439-G
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
To ensure proper polypeptide folding, oligomerization and transport, elaborate molecular 'chaperone machines' have evolved. These machines are usually composed of a major chaperone protein that binds promiscuously to nascent, unfolded, misfolded or aggregated polypeptides and a set of chaperone 'cohorts', whose function is to enhance efficiency and ensure recycling. These chaperone machines can function by themselves or synergistically to carry out their various tasks.
引用
收藏
页码：295 / 299
页数：5
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