NONRANDOM MIGRATION OF CD4+, CD8+, AND GAMMA,DELTA+T19+ LYMPHOCYTE SUBSETS FOLLOWING INVIVO STIMULATION WITH ANTIGEN

被引：10
|
作者：
KIMPTON, WG
WASHINGTON, EA
CAHILL, RNP
机构：
[1] Department of Veterinary Preclinical Sciences, The University of Melbourne, Parkville
来源：
CELLULAR IMMUNOLOGY | 1990年 / 130卷 / 01期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0008-8749(90)90178-T
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We report here the results of experiments in which the migration of three T cell subsets (CD4+, CD8+, and γδ+ T19+ cells) through antigen-stimulated lymph nodes and subcutaneous granulomas has been compared with that through normal skin and resting lymph nodes. The percentage of γδ+T19+ lymphocytes was halved and the percentage of CD8+ lymphocytes was doubled in lymph draining stimulated compared with control tissues, and all lymphocyte subsets except γδ+T19+ lymphocytes had higher hourly outputs in lymph draining antigen-stimulated compared with control tissues. Antigen also resulted in a higher percentage of CD8+ lymphoblasts and a lower percentage of γδ+T19+ lymphoblasts in efferent lymph draining antigen-stimulated lymph nodes. The data indicate that lymphocyte subsets leave the blood with differing efficiencies in different vascular beds and raise the possibility that antigen can influence the rate at which tissues extract individual T cell subsets from the blood. © 1990.
引用
收藏
页码：236 / 243
页数：8
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