REPEATED STRESSFUL EXPERIENCES DIFFERENTLY AFFECT BRAIN DOPAMINE RECEPTOR SUBTYPES

被引：24
|
作者：
PUGLISIALLEGRA, S [1 ]
KEMPF, E [1 ]
SCHLEEF, C [1 ]
CABIB, S [1 ]
机构：
[1] CNRS,CTR NEUROCHIM,INSERM,F-67084 STRASBOURG,FRANCE
来源：
LIFE SCIENCES | 1991年 / 48卷 / 13期
关键词：
D O I：
10.1016/0024-3205(91)90521-C
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The binding of tritiated spiperone (D2 antagonist) and tritiated SCH 23390 (D1 antagonist), in vivo, was investigated in the caudatus putamen (CP) and nucleus accumbens septi (NAS) of mice submitted to ten daily restraint stress sessions. Mice sacrificed 24 hr after the last stressful experience presented a 64% decrease of D2 receptor density (Bmax) but no changes in D1 receptor density in the NAS. In the CP a much smaller (11%) reduction of D2 receptor density was accompanied by a 10% increase of D1 receptors. These results show that the two types of dopamine (DA) receptors adapt in different or even opposite ways to environmental pressure, leading to imbalance between them.
引用
收藏
页码：1263 / 1268
页数：6
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