PHARMACOLOGICAL PROPERTIES OF BLOOD-PRESSURE AND HEART-RATE CONTROL IN SUNCUS

被引：7
|
作者：
MATSUKI, N
SAKUMA, Y
SAITO, H
机构：
[1] Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
来源：
JAPANESE JOURNAL OF PHARMACOLOGY | 1993年 / 62卷 / 01期
关键词：
BLOOD PRESSURE CONTROL; SPECIES-DEPENDENT DIFFERENCE; VAGUS REFLEX; SUNCUS;
D O I：
10.1254/jjp.62.93
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Blood pressure and heart rate and responses to various physiological substances in suncus were characterized and compared with those in mice. The blood pressures of the two species were similar, but the heart rate of suncus (about 400 beat/min) was significantly lower than that of mice. Norepinephrine increased the blood pressure but decreased the heart rate in suncus. The latter was blocked by cervical vagotomy. Sensitivities to acetylcholine and isoproterenol were lower in suncus. These results suggest that regulation of blood pressure and heart rate in suncus is very unique and different from the well-defined system of the rodents.
引用
收藏
页码：93 / 97
页数：5
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