PERIPHERAL NEUROPATHY CAUSED BY ANTIEPILEPTIC DRUGS - NEUROPHYSIOLOGICAL STUDY OF THE A-DELTA-FIBER AND C-FIBER

被引：3

作者：

BALDINI, S ^{[1
]}

CARENINI, L ^{[1
]}

LEONE, M ^{[1
]}

DALESSANDRO, G ^{[1
]}

BOTTACCHI, E ^{[1
]}

机构：

[1] OSPED REG AOSTA,REPARTO NEUROL & NEUROFISIOPATOL,VIA GINEVRA 3,I-11100 AOSTA,ITALY

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1992年 / 13卷 / 03期

关键词：

ANTIEPILEPTIC DRUGS; A-DELTA-FIBER AND C-FIBER; THERMAL THRESHOLD TEST; PERIPHERAL NEUROPATHY;

D O I：

10.1007/BF02224395

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The risk that antiepileptic drugs may cause damage to the peripheral nervous system led us to investigate 12 patients on carbamazepine and 12 patients on phenobarbital with the thermal threshold test. The heat and cold thresholds were measured at the ankle and wrist and, compared with those in 30 healthy subjects, they proved to be significantly higher. When the two groups of epileptics were compared separately with the controls, their thresholds were always higher. These findings are consistent with a toxic effect of both drugs on fine peripheral nerve fibers.

引用

页码：233 / 238

页数：6

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