A PROTON-DETECTED HETERONUCLEAR CHEMICAL-SHIFT CORRELATION EXPERIMENT WITH IMPROVED RESOLUTION AND SENSITIVITY

被引：80
作者：
ZUIDERWEG, ERP
机构：
[1] NMR Research, Pharmaceutical Discovery Division, Abbott Laboratories, Abbott Park
来源：
JOURNAL OF MAGNETIC RESONANCE | 1990年 / 86卷 / 02期
关键词：
D O I：
10.1016/0022-2364(90)90265-B
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A proton-detected heteronuclear chemical-shift correlation experiment is proposed that partially eliminates the induced heteronucleas-remote-proton coupling present in the routinely used heteronuclear multiple-quantum correlation (HMQC) experiment. As is demonstrated with natural-abundance 133C1H chemical-shift correlations of lysozyme, the partial remote-proton decoupling obtained in the new experiment results in significant improvements in resolution and sensitivity as compared to the HMQC experiment. © 1990.
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页码：346 / 357
页数：12
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