PREVENTION OF PROGRAMMED CELL-DEATH OF SYMPATHETIC NEURONS BY THE BCL-2 PROTOONCOGENE

被引:711
|
作者
GARCIA, I
MARTINOU, I
TSUJIMOTO, Y
MARTINOU, JC
机构
[1] UNIV GENEVA,MED CTR,DEPT PHARMACOL & CLIN NEUROPHYSIOL,CH-1211 GENEVA 4,SWITZERLAND
[2] UNIV GENEVA,MED CTR,DEPT PATHOL,CH-1211 GENEVA 4,SWITZERLAND
[3] WISTAR INST,PHILADELPHIA,PA 19104
关键词
D O I
10.1126/science.1411528
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Approximately half of the neurons produced during embryogenesis normally die before adulthood. Although target-derived neurotrophic factors are known to be major determinants of programmed cell death-apoptosis-the molecular mechanisms by which trophic factors interfere with cell death regulation are largely unknown. Overexpression of the bcl-2 proto-oncogene in cultured sympathetic neurons has now been shown to prevent apoptosis normally induced by deprivation of nerve growth factor. This finding, together with the previous demonstration of bcl-2 expression in the nervous system, suggests that the Bcl-2 protein may be a major mediator of the effects of neurotrophic factors on neuronal survival.
引用
收藏
页码:302 / 304
页数:3
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