Heart Failure with Preserved Ejection Fraction

Heart failure with preserved ejection fraction (HFpEF) affects approximately half of all patients with heart failure and is a common reason for admission to the hospital. The most common factors associated with developing HFpEF include age, female sex, uncontrolled hypertension, and obesity. Management of HFpEF consists of symptomatic control with diuretics and controlling comorbidities such as hypertension and atrial arrhythmias. Choice of antihypertensive is guided by underlying comorbidities; studies have shown no mortality benefit with angiotensin-converting enzyme (ACE) inhibitors or angiotensin receptor blockers (ARBs). However, ACE inhibitors and ARBs showed some reduction in hospital readmissions for patients with HFpEF.