Regulation mechanisms controlling fetal hemoglobin expression

被引：1
|
作者：
Labie, Dominique [1 ,2 ]
机构：
[1] Univ Paris 05, Inst Cochin, CNRS, UMR 8104, Paris, France
[2] Inserm U1016, Paris, France
来源：
HEMATOLOGIE | 2010年 / 16卷 / 03期
关键词：
Fetal hemoglobin; ontogeny; quantitative control; trans regulation;
D O I：
10.1684/hma.2010.0428
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Expression of fetal hemoglobin (HbF) among adult individuals is highly variable and has been studied by many approaches. Indeed such a variability can be considered as a general model, it is also of major value for modifyng the severity of hemoglobinopathies. Modulating factors demonstrated in cis to the beta-globin gene were not sufficient to explain this variability. More recently several quantitative trait loci (QTL) were identified in trans to the gene. One of those QTL, BCL11A on chromosome 2, is itself under control of ontogenic development; it might explain the normal HbF. HbA switch and its pathophysiological deregulation. Fetal hemoglobin, ontogeny, quantitative control, trans regulation
引用
收藏
页码：235 / 243
页数：9
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