IRON OVERLOAD IN BETA(2)-MICROGLOBULIN-DEFICIENT MICE

被引：167
|
作者：
DESOUSA, M
REIMAO, R
LACERDA, R
HUGO, P
KAUFMANN, SHE
PORTO, G
机构：
[1] NATL JEWISH CTR IMMUNOL & RESP MED,HOWARD HUGHES MED INST,DEPT MED,DENVER,CO 80206
[2] UNIV ULM,DEPT IMMUNOL,W-7900 ULM,GERMANY
来源：
IMMUNOLOGY LETTERS | 1994年 / 39卷 / 02期
基金：
英国医学研究理事会;
关键词：
IRON; T LYMPHOCYTE; MUTANT MICE;
D O I：
10.1016/0165-2478(94)90094-9
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The present paper describes the results of a comparative histological and quantitative analysis of iron distribution in tissues of beta(2)m - / - and beta(2)m + / - mice of different ages. Progressive hepatic iron overload, indistinguishable from that observed in human hemochromatosis, was found only in mice homozygous for the mutated beta(2)m gene. Total iron measurements done by flame atomic absorption showed statistically significant differences between liver samples from 5 beta(2)m + / - heterozygotes (468 +/- 174 mu g/g of dry weight) and 9 mice homozygous for the mutated beta(2)m gene with average total hepatic iron levels of 1583 +/- 424 mu g/g of dry weight.
引用
收藏
页码：105 / 111
页数：7
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